Monoclonal Antibody to ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/528 + 2F3.2)
Selected Variant
36-1815-100
Size: 100 µg
ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells. Control of this protein translation is via the IgVH gene. ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well. Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.
Product Specifications
Product Name Alternative
ZAP70||SRK
Gene Name
ZAP70
Gene ID
7535
UniProt
P43403
Host
Mouse
Reactivity
Human
Immunogen
Target Antigen
ZAP70 (Chronic Lymphocytic Leukemia Marker)
Clonality
Monoclonal
Clone
ZAP70/528 + 2F3.2
Applications
IHC
Purification
Affinity Chromatography
Format
Purified
Components
100 μg in 500 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Isotype
Mouse IgG2a, kappa + Mouse IgG2a, kappa
Price
Frequently Asked Questions
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