Monoclonal Antibody to CD71 / Transferrin Receptor (TFRC) (Clone : 66IG10)
It recognizes a ~90-95kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190kDa. This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Its epitope is localized in the extracellular domain of CD71. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.
Product Specifications
Product Name Alternative
TFRC
Gene Name
TFRC
Gene ID
7037
UniProt
P02786
Host
Mouse
Reactivity
Human
Immunogen
Human thymocytes (T-cells)
Target Antigen
CD71 / Transferrin Receptor (TFRC)
Clonality
Monoclonal
Clone
66IG10
Applications
ELISA, FACS, IF
Purification
Affinity Chromatography
Format
Purified
Components
100 μg in 500 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
ELISA (Use Ab at 2-4ug/ml for coating) (Order Ab without BSA) ; Flow Cytometry (1-2ug/million cells) ; Immunofluorescence (1-2ug/ml)
Isotype
Mouse IgG1, kappa
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