Monoclonal Antibody to Cyclin D1 (G1-Cyclin & Mantle Cell Marker) (Clone : CCND1/809) -PE
Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t (11; 14) (q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative) . Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
Product Specifications
Product Name Alternative
CCND1||BCL1||PRAD1
Gene Name
CCND1
Gene ID
595
UniProt
P24385
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human CCND1 protein
Target Antigen
Cyclin D1 (G1-Cyclin & Mantle Cell Marker)
Clonality
Monoclonal
Clone
CCND1/809
Applications
FACS, IF
Purification
Affinity Chromatography
Format
Purified
Components
PE conjugated CYclin D1 Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.
Storage Conditions
Store the antibody at 4°C; stable for 6 months.
Applications Notes
Flow Cytometry (5ul per test per one million cells or 5ul per 100ul of whole blood) ; Immunofluorescence (1:50-1:100 for 30 minutes at RT)
Isotype
Mouse IgG2a, kappa
Conjugate
PE
Frequently Asked Questions
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