Monoclonal Antibody to Cyclin D1 (G1-Cyclin & Mantle Cell Marker) (Clone : CCND1/809)
Selected Variant
36-1637-100
Size: 100 µg
Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t (11; 14) (q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative) . Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
Product Specifications
Product Name Alternative
CCND1||BCL1||PRAD1
Gene Name
CCND1
Gene ID
595
UniProt
P24385
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human CCND1 protein
Target Antigen
Cyclin D1 (G1-Cyclin & Mantle Cell Marker)
Clonality
Monoclonal
Clone
CCND1/809
Applications
FACS, IHC
Purification
Affinity Chromatography
Format
Purified
Components
100 μg in 500 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Isotype
Mouse IgG2a, kappa
Price
Frequently Asked Questions
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