Monoclonal Antibody to Cyclin D1 (G1-Cyclin & Mantle Cell Marker) (Clone : SPM587)
Selected Variant
36-1635-100
Size: 100 µg
Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t (11; 14) (q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative) . Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
Product Specifications
Product Name Alternative
CCND1||BCL1||PRAD1
Gene Name
CCND1
Gene ID
595
UniProt
P24385
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Human recombinant full length cyclin D1 protein
Target Antigen
Cyclin D1 (G1-Cyclin & Mantle Cell Marker)
Clonality
Monoclonal
Clone
SPM587
Applications
FACS, IF, WB, IHC
Purification
Affinity Chromatography
Format
Purified
Components
100 μg in 500 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Isotype
Mouse IgG2a, kappa
Price
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
CD27 (Tumor Necrosis Factor Receptor Superfamily 7) (rLPFS2/1611), 0.2mg/mL
PLAP (Placental Alkaline Phosphatase) (GM022), CF647 conjugate, 0.1mg/mL
Anti-MIG/CXCL9 Antibody Picoband®, FITC Conjugate
SOX10 (SOX10/991 + SOX10/1074), Biotin conjugate, 0.1mg/mL
