Monoclonal Antibody to Beta-2 Microglobulin (Renal Failure & Tumor Marker) (Clone : B2M/1118)

Î22 microglobulin is a 12KDa protein with a pI of 5.6. Serum Î22 microglobulin levels are a reflection of cell turnover. Levels rise with fever, inflammation, and infection. Increased serum levels are also seen in B-cell malignancies and in renal failure and may indicate a worse prognosis for patients with early-stage Hodgkin's lymphoma. In urine, increased levels are seen in proximal renal tubular disease as well as renal transplant rejection. Î22 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumours and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy) .

Product Specifications

Product Name Alternative

B2M||CDABP0092||HDCMA22P

Gene Name

B2M

Gene ID

567

UniProt

P61769

Host

Mouse

Reactivity

Human

Immunogen

Full length recombinant human B2M protein

Target Antigen

Beta-2 Microglobulin (Renal Failure & Tumor Marker)

Clonality

Monoclonal

Clone

B2M/1118

Applications

FACS, WB, IF, IHC

Purification

Affinity Chromatography

Format

Purified

Components

100 μg in 500 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.

Storage Conditions

Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.

Applications Notes

Flow Cytometry (1-2ug/million cells) ; Western Blot (1-2ug/ml) ; Immunofluorescence (1-2ug/ml) ; Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes)