Monoclonal Antibody to UACA / Nucling (Nuclear Membrane Marker) (Clone : AE-5)
UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.
Product Specifications
Product Name Alternative
UACA||KIAA1561
Gene Name
UACA
Gene ID
55075
UniProt
Q9BZF9
Host
Mouse
Reactivity
Human, Mouse
Immunogen
Nuclei of myeloid leukemia biopsy cells
Target Antigen
UACA / Nucling (Nuclear Membrane Marker)
Clonality
Monoclonal
Clone
AE-5
Applications
FACS, IF, WB
Purification
Affinity Chromatography
Format
Purified
Components
100 μg in 500 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Flow Cytometry (1-2ug/million cells) ; Immunofluorescence (1-2ug/ml) ; Western Blot (1-2ug/ml)
Isotype
Mouse IgG1, kappa
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