Monoclonal Antibody to NKX2.2 (Neuroendocrine & Ewing Sarcoma Marker) (Clone : SPM564)
Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.
Product Specifications
Product Name Alternative
NKX2-2||NKX2.2||NKX2B
Gene Name
NKX2-2
Gene ID
4821
UniProt
O95096
Host
Mouse
Reactivity
Human, Mouse, rat
Immunogen
Human NKX2.2 recombinant protein
Target Antigen
NKX2.2 (Neuroendocrine & Ewing Sarcoma Marker)
Clonality
Monoclonal
Clone
SPM564
Applications
FACS, IF, IHC
Purification
Affinity Chromatography
Format
Purified
Components
100 μg in 500 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Isotype
Mouse IgG2b, kappa
Frequently Asked Questions
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