Monoclonal Antibody to MUC18 / CD146 / MCAM (Melanoma Cell Adhesion Molecule) (Clone : MCAM/1101)
Selected Variant
36-1416-100
Size: 100 µg
The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.
Product Specifications
Product Name Alternative
MCAM||MUC18
Gene Name
MCAM
Gene ID
4162
UniProt
P43121
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human MCAM protein
Target Antigen
MUC18 / CD146 / MCAM (Melanoma Cell Adhesion Molecule)
Clonality
Monoclonal
Clone
MCAM/1101
Applications
FACS, IF, IHC
Purification
Affinity Chromatography
Format
Purified
Components
100 μg in 500 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Isotype
Mouse IgG1, kappa
Price
Frequently Asked Questions
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