Monoclonal Antibody to Lambda Light Chain (B-Cell Marker) (Clone : ICO-106)
This MAb is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.
Product Specifications
UniProt
P01701
Host
Mouse
Reactivity
Human
Immunogen
Purified human IgG
Target Antigen
Lambda Light Chain (B-Cell Marker)
Clonality
Monoclonal
Clone
ICO-106
Applications
ELISA
Purification
Affinity Chromatography
Format
Purified
Components
100 μg in 500 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
ELISA (For coating use Ab at 1-5ug/ml, order Ab without BSA)
Isotype
Mouse IgG1, kappa
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