Monoclonal Antibody to TRIM29 (Lung Squamous Cell Carcinoma Marker) (Clone : TRIM29/1042)
It recognizes a 66kDa protein, which is identified as Tripartite motif-containing protein 29 (TRIM29) . It interacts with the intermediate filament protein vimentin, a substrate for the PKC family of protein kinases, and with hPKCI-1, an inhibitor of the PKCs. TRIM29 protein contains both zinc finger and leucine zipper motifs, suggesting that the it may form homodimers and possibly associate with DNA. High expression of TRIM29 has been reported in gastric cancer and pancreatic cancer, and correlates with enhanced tumor growth and lymph node metastasis. TRIM29 is also able to distinguish lung squamous cell carcinoma from lung adenocarcinoma with ~90% positive accuracy, when used in a panel with TTF-1, p63, CK5/6, and Napsin-A antibodies.
Product Specifications
Product Name Alternative
TRIM29||ATDC
Gene Name
TRIM29
Gene ID
23650
UniProt
Q14134
Host
Mouse
Reactivity
Human
Immunogen
Recombinant fragment (126 Amino acid residues between aa 1-200) of human TRIM29 protein
Target Antigen
TRIM29 (Lung Squamous Cell Carcinoma Marker)
Clonality
Monoclonal
Clone
TRIM29/1042
Applications
WB
Purification
Affinity Chromatography
Format
Purified
Components
100 μg in 500 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western Blot (1-2ug/ml)
Isotype
Mouse IgG2b, kappa
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