Polyclonal Antibody to CUEDC2
Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism. Zhang P.-J., Zhao J., Li H.-Y. EMBO J. 26:1831-1842 (2007)
Product Specifications
Product Name Alternative
C10orf66|| bA18I14.5
Gene Name
CUEDC2
Gene ID
79004
UniProt
Q9H467
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Peptide sequence around aa.262~266 (D-V-R-N-P) derived from Human CUEDC2.
Target Antigen
CUEDC2
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 32kd, Western blotting: 1:500~1:1000
Isotype
Rabbit IgG
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