Polyclonal Antibody to Twist2
Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors. Lee M.S., Lowe G., Flanagan S., Kuchler K., Glackin C.A.Bone 27:591-602 (2000)
Product Specifications
Product Name Alternative
DERMO1|| MGC117334|| bHLHa39
Gene Name
TWIST2
Gene ID
117581
UniProt
Q8WVJ9
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide sequence around aa.26~30 (P-K-R-F-G) derived from Human Twist2.
Target Antigen
Twist2
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blotting1:100-1:500, Immunohistochemistry 1:100-1:500
Isotype
Rabbit IgG
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