Polyclonal Antibody to NAC1
Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. A BTB/POZ protein, NAC-1, is related to tumor recurrence and is essential for tumor growth and survival." Nakayama K., Nakayama N., Davidson B., et al. Proc. Natl. Acad. Sci. U.S.A. 103:18739-18744 (2006) "NAC-1 controls cell growth and survival by repressing transcription of Gadd45GIP1, a candidate tumor suppressor."
Product Specifications
Product Name Alternative
BEND8|| NACC1|| NAC-1|| BTBD14B|| FLJ37383
Gene Name
NACC1
Gene ID
112939
UniProt
Q96RE7
Host
Rabbit
Reactivity
Rat, Mouse, Human
Immunogen
Peptide sequence around aa.519~523 (A-G-P-S-A) derived from Human NAC1
Target Antigen
NAC1
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 62kd, Western blotting: 1:500~1:1000
Isotype
Rabbit IgG
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