Polyclonal Antibody to NMDANR2B Subunit
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death
Product Specifications
Product Name Alternative
GRIN2B, NMDE2, NME2, NR2B, NR3
Gene Name
GRIN2B
Gene ID
2904
UniProt
Q13224
Host
Rabbit
Reactivity
Rat, Mouse, Human
Immunogen
Peptide sequence around aa.1250-1254 (N-L-Y-D-I) derived from Human NMDANR2B Subunit.
Target Antigen
NMDANR2B Subunit
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 180kd, Western blotting: 1:500~1:1000
Isotype
Rabbit IgG
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