Polyclonal Antibody to eIF4B (Ab-422)
Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. Gingras, A.C. et al. (2001) Genes Dev. 15, 807-826. Duncan, R. and Hershey, J.W. (1985) J. Biol. Chem. 260, 5493-5497. Duncan, R.F. and Hershey, J.W. (1989) J. Cell Biol. 109, 1467-1481.
Product Specifications
Product Name Alternative
EIF4B
Gene Name
EIF4B
Gene ID
1975
UniProt
P23588
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide sequence around aa.420~424 (T-G-S-E-S) derived from Human eIF4B.
Target Antigen
EIF4B (Ab-422)
Clonality
Polyclonal
Applications
WB, IHC
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 80kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Isotype
Rabbit IgG
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