Polyclonal Antibody to PI3 Kinase p85/p55 (Ab-467/199)
PI3K binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Stoyanov, B. et al. (1995) Science 269, 690-3. Simpson, L. and Parsons, R. (2001) Exp Cell Res 264, 29-41. Neri, L.M. et al. (2002) Biochim Biophys Acta 1584, 73-80.
Product Specifications
Product Name Alternative
P85||AGM7||p85-ALPHA||p55||p55-GAMMA
Gene Name
PIK3R1
Gene ID
5295
UniProt
P27986 /Q92569
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide sequence around aa.465~469 (L-Y-E-E-Y) derived from Human PI3 Kinase p85/p55.
Target Antigen
PI3 Kinase p85/p55 (Ab-467/199)
Clonality
Polyclonal
Applications
IHC
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 55, 85kd, Immunohistochemistry: 1:50~1:100
Isotype
Rabbit IgG
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