Polyclonal Antibody to CD22
Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to a-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Product Specifications
Product Name Alternative
SIGLEC2|| FLJ22814|| SIGLEC-2|| MGC130020
Gene Name
CD22
Gene ID
933
UniProt
P20273
Host
Rabbit
Reactivity
Human
Immunogen
Peptide sequence around aa.839~843 (N-V-D-Y-V) derived from Human CD22.
Target Antigen
CD22
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 140kd, Western blotting: 1:500~1:1000
Isotype
Rabbit IgG
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