Polyclonal Antibody to AML1 (RUNX1)
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The a subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits MYST4-dependent transcriptional activation.
Product Specifications
Product Name Alternative
CBFA2|| EVI-1|| AMLCR1
Gene Name
RUNX1
Gene ID
861
UniProt
Q01196
Host
Rabbit
Reactivity
Human
Immunogen
Peptide sequence around aa.6~10 (D-A-S-T-S) derived from Human AML1 (RUNX1) .
Target Antigen
AML1 (RUNX1)
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 55kd, Western blotting: 1:500~1:1000
Isotype
Rabbit IgG
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