Polyclonal Antibody to ABCG2 (CD338)
Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine.
Product Specifications
Product Name Alternative
BMDP|| MRX|| ABC15|| ABCP|| BCRP1
Gene Name
BMDP
Gene ID
9429
UniProt
Q9UQ0
Host
Rabbit
Reactivity
Human
Immunogen
Peptide sequence around aa.160~164 (R-I-N-R-V) derived from Human ABCG2 (CD338) .
Target Antigen
ABCG2 (CD338)
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 65-80kd, Western blotting: 1:500
Isotype
Rabbit IgG
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