Polyclonal Antibody to REST
Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
Product Specifications
Product Name Alternative
NRSF|| XBR|| REST
Gene Name
REST
Gene ID
5978
UniProt
Q13127
Host
Rabbit
Reactivity
Human
Immunogen
Peptide sequence around aa.873~877 (R-E-E-A-S) derived from Human REST.
Target Antigen
REST
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 121kd, Western blotting: 1:500~1:1000
Isotype
Rabbit IgG
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