Polyclonal Antibody to E-Cadherin (CD324)
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin a-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
Product Specifications
Product Name Alternative
CDH1|| CDHE|| UVO
Gene Name
CDH1
Gene ID
999
UniProt
P12830
Host
Rabbit
Reactivity
Rat, Mouse, Human
Immunogen
Peptide sequence around aa.864~868 (E-W-G-N-R) derived from Human E-Cadherin.
Target Antigen
E-Cadherin (CD324)
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 135kd, Western blotting: 1:500~1:1000
Isotype
Rabbit IgG
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