Polyclonal Antibody to CD44
Receptor for hyaluronic acid (HA) . Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs) . Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Teriete P., et.al (2004) Mol. Cell 13:483-496 Bartolazzi A. (2003) Melanoma Res. 13:325-337 Liu T.et.al (2005) J. Proteome Res. 4:2070-2080
Product Specifications
Product Name Alternative
LHR|| MDU2|| MDU3|| MIC4
Gene Name
CD44
Gene ID
960
UniProt
P16070
Host
Rabbit
Reactivity
Human
Immunogen
Peptide sequence around aa.734~738 (Q-N-V-D-M) derived from Human CD44.
Target Antigen
CD44
Clonality
Polyclonal
Applications
WB, IF
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 80kd, Western blotting: 1:500~1:1000, Immunofluorescence:1:100~1:200
Isotype
Rabbit IgG
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