Polyclonal Antibody to MAP2K4
SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflamatory cytokines (1-3) . Activation of SEK1 occurs through MEKK phosphorylation of serine and threonine residues at positions 257 and 261, respectively. Like MEK, SEK is a dual-specificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop (4) . Phosphorylation by Akt at Ser80 inhibits SEK1 and suppresses stress-activated signal transduction (5) .
Product Specifications
Product Name Alternative
JNKK1|| MEK4|| MKK4|| PRKMK4|| SERK1
Gene Name
MAP2K4
Gene ID
6416
UniProt
P45985
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide sequence around aa.352~356 (E-S-K-R-P) derived from Human MAP2K4.
Target Antigen
MAP2K4
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 44kd, Western blotting: 1:500~1:1000
Isotype
Rabbit IgG
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