Polyclonal Antibody to MDM2
MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 . Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53 . Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53 .
Product Specifications
Product Name Alternative
HDMX|| hdm2
Gene Name
MDM2
Gene ID
4193
UniProt
Q00987
Host
Rabbit
Reactivity
Human
Immunogen
Peptide sequence around aa.18~22 (Q-I-P-A-S) derived from Human MDM2.
Target Antigen
MDM2
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 90kd, Western blotting: 1:500~1:1000
Isotype
Rabbit IgG
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