Polyclonal Antibody to Caspase 3
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly (ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Gervais, F. G et al.Cell 97: 395-406, 1999. Nicholson, D. W. et al. (1995) Nature 376, 37-43.
Product Specifications
Product Name Alternative
Apopain
Gene Name
CASP3
Gene ID
836
UniProt
P42574
Host
Rabbit
Reactivity
Human
Immunogen
Peptide sequence around aa.29~33 (S-G-I-S-L) derived from Caspase 3.
Target Antigen
Caspase 3
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 35 17kd, Western blotting: 1:1000
Isotype
Rabbit IgG
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