Polyclonal Antibody to Fas
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro) .
Product Specifications
Product Name Alternative
FASLG receptor|| Apoptosis-mediating surface antigen FAS|| Apo-1 antigen
Gene Name
FAS
Gene ID
355
UniProt
P25445
Host
Rabbit
Reactivity
Human
Immunogen
Peptide sequence around aa.323~327 (E-N-S-N-F) derived from human Fas .
Target Antigen
Fas
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 40-50kd, Western blotting: 1:1000
Isotype
Rabbit IgG
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