Polyclonal Antibody to CRY1
Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL Morioka N, et al. (2010) J Pharmacol Sci.113 (3) :234-45. Fonseca F, et al. (2010) Mol Diagn Ther.14 (3) :171-8. Stratmann M, et al. (2010) Genes Dev.24 (12) :1317-28.
Product Specifications
Product Name Alternative
PHLL1
Gene Name
CRY1
Gene ID
1407
UniProt
Q16526
Host
Rabbit
Reactivity
Mouse
Immunogen
Peptide sequence around aa.551~555 (S-Q-G-S-G) derived from Human CRY1.
Target Antigen
CRY1
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 60kd, Western blotting: 1:500~1:1000
Isotype
Rabbit IgG
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