Polyclonal Antibody to Melanoma-associated antigen D1
Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Binds p75NTR and antagonizes its association with TrkA, inhibits cell cycle progression, and facilitates p75NTR-mediated apoptosis. May act as a regulator of the function of DLX family members. May regulate p53 transcriptional activity and inhibit cell proliferation. Enhances p53 phosphorylation and accumulation. Zhao Z, et al. (2002) Sci China C Life Sci.45 (4) :412-20. Shen WG, et al. (2007) Cell Commun Adhes.14 (1) :21-31. Cheresh DA, et al. (1984) J Biol Chem.259 (12) :7453-9.
Product Specifications
Product Name Alternative
MAGED1
Gene Name
Maged1
Gene ID
94275
UniProt
Q9QYH6
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide with sequence C-EAEARAEARNRMGIGDE derived from Mouse Melanoma-associated antigen D1.
Target Antigen
Melanoma-associated antigen D1
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 95kd, Western blotting: 1:500~1:1000
Isotype
Rabbit IgG
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