Polyclonal Antibody to TrkA (Ab-791)
Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF) . Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.
Product Specifications
Product Name Alternative
High affinity nerve growth factor receptor precursor|| NTRK1|| Slow nerve growth factor receptor|| TRK|| TRK1 transforming tyrosine kinase protein
Gene Name
NTRK1
Gene ID
4914
UniProt
P04629
Host
Rabbit
Reactivity
Human
Immunogen
Peptide sequence around aa.789~793 (P-V-Y-L-D) derived from Human TrkA.
Target Antigen
TrkA (Ab-791)
Clonality
Polyclonal
Applications
IF
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 140kd, Immunofluorescence: 1:100~1:200
Isotype
Rabbit IgG
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