Polyclonal Antibody to Alpha-Synuclein (Ab-133)
May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies) . Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
Product Specifications
Product Name Alternative
NACP|| SYN|| SYUA|| alpha-synuclein
Gene Name
SNCA
Gene ID
6622
UniProt
P37840
Host
Rabbit
Reactivity
Rat, Mouse, Human
Immunogen
Peptide sequence around aa. 131~135 (E-G-Y-Q-D) derived from Human a-Synuclein.
Target Antigen
Alpha-Synuclein (Ab-133)
Clonality
Polyclonal
Applications
WB, IF
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 18kd, Western blotting: 1:500~1:1000, Immunofluorescence: 1:100~1:200
Isotype
Rabbit IgG
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