Polyclonal Antibody to Cortactin (Ab-466)
Cortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene. Luo C, et al. (2006) J Biol Chem ; 281 (40) :30081-30093 Head JA, et al. (2003) Mol Biol Cell ;14 (8) :3216-3229 Li Y, et al. (2000) J Biol Chem ; 275 (47) : 37187-37193 Kinley AW, et al. (2003) Curr Biol ; 13 (5) : 384-393
Product Specifications
Product Name Alternative
Amplaxin|| CTTN|| EMS1|| SRC8
Gene Name
CTTN
Gene ID
2017
UniProt
Q14247
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Peptide sequence around aa.464~468 (P-V-Y-E-T) derived from Human CORTACTIN.
Target Antigen
Cortactin (Ab-466)
Clonality
Polyclonal
Applications
WB, IHC
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 85kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Isotype
Rabbit IgG
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