Polyclonal Antibody to IRS-1 (Ab-639)
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit Tzatsos A, et al. (2006) Mol Cell Biol; 26 (1) : 63-76 Kadowaki T, et al. (2000) J Clin Invest; 106 (4) : 459-465 Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98 (8) : 4640-4645 Szanto I, et al. (2000) Proc Natl Acad Sci U S A; 97 (5) : 2355-2360
Product Specifications
Product Name Alternative
IRS-1|| IRS1
Gene Name
IRS1
Gene ID
3667
UniProt
P35568
Host
Rabbit
Reactivity
Rat, Mouse, Human
Immunogen
Peptide sequence around aa.637~641 (P-K-S-V-S) derived from Human IRS-1.
Target Antigen
IRS-1 (Ab-639)
Clonality
Polyclonal
Applications
WB, IF
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 180kd, Western blotting: 1:500~1:1000, Immunofluorescence: 1:100~1:200
Isotype
Rabbit IgG
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