Polyclonal Antibody to PDGF Receptor beta (Ab-751)
PDGF Receptor b encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor a and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
Product Specifications
Product Name Alternative
PDGFR||PDGFR1
Gene Name
PDGFRB
Gene ID
5159
UniProt
P09619
Host
Rabbit
Reactivity
Rat, Human
Immunogen
Peptide sequence around aa.749~753 (V-D-Y-V-P) derived from Human PDGFRb.
Target Antigen
PDGF Receptor Beta (Ab-751)
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 190kd, Western blotting: 1:500~1:1000
Isotype
Rabbit IgG
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