Polyclonal Antibody to FAK (Ab-397)
Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Positive regulator of cyclin D-dependent kinases such as CDK4. Regulated by phosphorylation and degradation events. von Sengbusch A, et al. (2005) Am J Pathol ; 166 (2) : 585-596 Fornaro M, et al. (2000) Mol Biol Cell ; 11 (7) : 2235-2249 Zhang X, et al. (1999) Proc Natl Acad Sci U S A; 96 (16) : 9021-9026.
Product Specifications
Product Name Alternative
FADK|| PTK2|| FAK1|| FRNK|| PTK2
Gene Name
PTK2
Gene ID
5747
UniProt
Q05397
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide sequence around aa. 395~399 (D-D-Y-A-E) derived from Human FAK.
Target Antigen
FAK (Ab-397)
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 125kd, Western blotting: 1:500~1:1000
Isotype
Rabbit IgG
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