Polyclonal Antibody to VASP (Ab-157)
Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. Zhao WM, et al. (2001) EMBO J 20 (9) : 2315-2325. Millard TH, et al. (2005) EMBO J 24 (2) : 240-250. K
Product Specifications
Product Name Alternative
VASP
Gene Name
VASP
Gene ID
7408
UniProt
P50552
Host
Rabbit
Reactivity
Human, Rat
Immunogen
Peptide sequence around aa.155~159 (R-V-S-N-A) derived from Human VASP.
Target Antigen
VASP (Ab-157)
Clonality
Polyclonal
Applications
WB, IF
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 50kd, Western blotting: 1:500~1:1000, Immunofluorescence: 1:100~1:200
Isotype
Rabbit IgG
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