Polyclonal Antibody to Zap-70 (Ab-319)
ZAP70 is a 70-kD tyrosine phosphoprotein that associates with the zeta chain and undergoes tyrosine phosphorylation following TCR stimulation. The ZAP70 gene is expressed in T- and natural KILLER cells. Protein-Tyrosine Kinases (PTKs) play an integral role in T-cell activation. Stimulation of the T-cell antigen receptor results in tyrosine phosphorylation of a number of cellular substrates. One of these is the TCR-zeta chain, which can mediate the transduction of extracellular stimuli into cellular effector functions Salomon AR, et al. (2003) Proc Natl Acad Sci U S A; 100 (2) : 443-448 Ku GM, et al. (2001) EMBO J; 20 (3) : 457-465 Tang J, et al. (1999) Proc Natl Acad Sci U S A; 96 (17) : 9775-9780 Zhao Q, et al. (1996) Mol Cell Biol; 16 (12) : 6765-6774 Williams BL, et al. (1999) EMBO J; 18 (7) : 1832-1844 Adjali O, et al. (2005) J Clin Invest; 115 (8) : 2287-2295.
Product Specifications
Product Name Alternative
70 kDa zeta-associated protein|| SRK|| Syk-related tyrosine kinase|| ZA70|| ZAP-70
Gene Name
ZAP70
Gene ID
7535
UniProt
P43403
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide sequence around aa.317~321 (S-P-Y-S-D) derived from Human ZAP70.
Target Antigen
Zap-70 (Ab-319)
Clonality
Polyclonal
Applications
WB, IHC
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 70kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Isotype
Rabbit IgG
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