Polyclonal Antibody to AFX (Ab-197)
Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle.
Product Specifications
Product Name Alternative
AFX|| FOXO4|| AFX1|| Afxh
Gene Name
FOXO4
Gene ID
4303
UniProt
P98177
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide sequence around aa. 195~199 (A-A-S-M-D) derived from Human AFX.
Target Antigen
AFX (Ab-197)
Clonality
Polyclonal
Applications
WB, IHC
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 65kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Isotype
Rabbit IgG
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