Polyclonal Antibody to FKHR (Ab-256)

FKHR belongs to the forkhead family of transcription factors, which are characterized by a distinct forkhead domain. It may play a role in myogenic growth and differentiation. The mammalian DAF-16-like transcription factors, FKHR, FKHRL1, and AFX, function as key regulators of insulin signaling, cell cycle progression, and apoptosis downstream of phosphoinositide 3-kinase. Gene activation through binding to insulin response sequences has been essential for mediating these functions. D-type Cyclins (in Class III) is required for FKHR mediated inhibition of cell cycle progression and transformation. FKHR gene is mapped to chromosome 13q14 Gan L, et al. (2005) J Neurochem; 93 (5) : 1209-19. Smith WW, et al. (2005) J Cell Biol; 169 (2) : 331-9. Di Maira G, et al. (2005) Cell Death Differ; 12 (6) : 668-77. Horn S, et al. (2004) Leukemia; 18 (11) : 1839-49. Zhao X, et al. (2004) Biochem J 4; 378 (Pt 3) : 839-49.