Polyclonal Antibody to FKHR (Ab-256)
FKHR belongs to the forkhead family of transcription factors, which are characterized by a distinct forkhead domain. It may play a role in myogenic growth and differentiation. The mammalian DAF-16-like transcription factors, FKHR, FKHRL1, and AFX, function as key regulators of insulin signaling, cell cycle progression, and apoptosis downstream of phosphoinositide 3-kinase. Gene activation through binding to insulin response sequences has been essential for mediating these functions. D-type Cyclins (in Class III) is required for FKHR mediated inhibition of cell cycle progression and transformation. FKHR gene is mapped to chromosome 13q14 Gan L, et al. (2005) J Neurochem; 93 (5) : 1209-19. Smith WW, et al. (2005) J Cell Biol; 169 (2) : 331-9. Di Maira G, et al. (2005) Cell Death Differ; 12 (6) : 668-77. Horn S, et al. (2004) Leukemia; 18 (11) : 1839-49. Zhao X, et al. (2004) Biochem J 4; 378 (Pt 3) : 839-49.
Product Specifications
Product Name Alternative
FOXO1
Gene Name
FOXO1
Gene ID
2308
UniProt
Q12778
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide sequence around aa.254~258 (A-A-S-M-D) derived from Human FKHR/FOXO1A.
Target Antigen
FKHR (Ab-256)
Clonality
Polyclonal
Applications
WB, IHC, IF
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 78-82 kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Isotype
Rabbit IgG
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