Polyclonal Antibody to ASK1 (Ab-966)
Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death. Zhang W, et al. (2005) J Biol Chem. 280 (19) : 19036-19044. Fujii K, et al. (2004) Oncogene. 23 (29) :5099-5104. Goldman EH, et al. (2004) J Biol Chem 2004 Mar 12; 279 (11) : 10442-10449. Zhang L, et al. (1999) Proc Natl Acad Sci U S A. 96 (15) : 8511-8515.
Product Specifications
Product Name Alternative
ASK-1|| M3K5|| MAP3K5|| MAPK/ERK kinase kinase 5|| MAPKKK5
Gene Name
MAP3K5
Gene ID
4217
UniProt
Q99683
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide sequence around aa.964~968 (S-I-S-L-P) derived from Human ASK1.
Target Antigen
ASK1 (Ab-966)
Clonality
Polyclonal
Applications
WB, IHC, IF
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 155kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Isotype
Rabbit IgG
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