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Polyclonal Antibody to ICAM-1 (Ab-512)

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin a-L/beta-2) . During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus. Greenwood J, et al. (2003) J Immunol; 171 (4) :2099-2108. Zhou Z, et al. (2005) Eur J Pharmacol; 513 (1-2) :1-8. Chen YH, et al. (2001) J Cell Biochem; 82 (3) :512-521

Product Specifications

Product Name Alternative

ICA1|| ICAM1

Gene Name

ICAM1

Gene ID

3383

UniProt

P05362

Host

Rabbit

Reactivity

Human

Immunogen

Peptide sequence around aa. 510~514 (K-K-Y-R-L) derived from Human ICAM-1.

Target Antigen

ICAM-1 (Ab-512)

Clonality

Polyclonal

Applications

WB

Format

Purified

Components

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage Conditions

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Applications Notes

Predicted MW: 89 92kd, Western blotting: 1:500~1:1000

Isotype

Rabbit IgG

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