Polyclonal Antibody to HER2 (Ab-877)
Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-a and amphiregulin. Dittadi, R. et al. (2000) J. Natl. Cancer Inst. 92, 1443-1444. Muthuswamy, S. K. et al. (1999) Mol. Cell. Biol. 19, 6845-6857. Qian, X. et al. (1994) Proc. Natl. Acad. Sci. USA 91, 1500-1504. Kwon, Y. K. et al. (1997) J. Neurosci. 17, 8293-8299. Klapper, L. N. et al. (2000) Cancer Res. 60, 3384-3388.
Product Specifications
Product Name Alternative
C-erbB-2|| ErbB2
Gene Name
ERBB2
Gene ID
2064
UniProt
P04626
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide sequence around aa.875~879 (T-E-Y-H-A) derived from Human HER2.
Target Antigen
HER2 (Ab-877)
Clonality
Polyclonal
Applications
WB, IHC
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 185kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Isotype
Rabbit IgG
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