Polyclonal Antibody to BCL-XL (Ab-62)
Potent inhibitor of cell death. Isoform Bcl-X (L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases By similarity. Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X (S) isoform promotes apoptosis.
Product Specifications
Product Name Alternative
BAD, BBC6, BCL2L8
Gene Name
BAD
Gene ID
572
UniProt
Q92934
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide sequence around aa.60~64 (A-D-S-P-A) derived from human BCL-XL .
Target Antigen
BCL-XL (Ab-62)
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 30kd, Western blotting: 1:500~1:1000
Isotype
Rabbit IgG
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