Polyclonal Antibody to Akt (Ab-308)

General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I) . Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. Tremblay F, et al. (2005) Diabetes; 54 (9) : 2674-84. Xu BE, et al. (2005) J Biol Chem; 280 (40) : 34218-23. Samuels Y, et al. (2005) Cancer Cell; 7 (6) : 561-73. Di Maira G, et al. (2005) Cell Death Differ; 12 (6) : 668-77.