Polyclonal Antibody to NF-KB-p105/p50 (Ab-907)
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NF-KB1/p105, NF-KB1/p50, REL and NF-KB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. Hou S, et al. (2003) J Biol Chem. 278 (46) : 45994-45998. Baeuerle P A, et al. (1994) Annu Rev Immunol. 12:141-179. Baeuerle P A, et al. (1996) Cell 87:13-20. Haskill S, et al. (1991) Cell 65:1281-1289.
Product Specifications
Product Name Alternative
DNA-binding factor KBF1|| EBP-1|| NF-kappa-B1 p84/NF-kappa-B1 p98|| NF-KB1|| NF-KB-p50
Host
Rabbit
Reactivity
Human
Immunogen
Peptide sequence around aa.905~909 (P-L-S-P-A) derived from Human NF-KB-p105.
Target Antigen
NF-KB-p105/p50 (Ab-907)
Clonality
Polyclonal
Applications
WB, IHC
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 120 kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Isotype
Rabbit IgG
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