Polyclonal Antibody to GSK3beta (Ab-9)
Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin.
Product Specifications
Product Name Alternative
Factor A||GSK-3 beta||Protein kinase GSK-3-beta||kinase GSK-3 beta
Gene Name
GSK3B
Gene ID
2932
UniProt
P49841
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide sequence around aa.7~11 (T-T-S-F-A) derived from Human GSK3b.
Target Antigen
GSK3 Beta (Ab-9)
Clonality
Polyclonal
Applications
WB, IHC, IF
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 46kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Isotype
Rabbit IgG
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