Beta-catenin (Phospho-Ser715) Antibody
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML
Product Specifications
Product Name Alternative
Catenin beta-1; CTNB1; CTNNB; CTNNB1
Gene Name
CTNNB1
Gene ID
1499
UniProt
P35222
Reactivity
Rat, Mouse, Human
Immunogen
Peptide sequence around phosphorylation site of serine 715 (D-P-S (p) -Y-R) derived from Human beta-catenin.
Target Antigen
Beta-catenin
Clonality
Polyclonal
Applications
IHC, WB
Purification
Affinity-chromatography
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store at 4°C; For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blotting: 1:500~1:1000
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