Polyclonal Antibody to TrkB (Phospho-Tyr705)
Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF) . Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1. Woronowicz A, et al. Glycobiology. 2007 Jan;17 (1) :10-24. Mojsilovic-Petrovic J, et al. J Neurosci. 2006 Sep 6;26 (36) :9250-63. Lewis MA, et al. Mol Pharmacol. 2006 Apr;69 (4) :1396-404. Cai D, et al. Physiol Genomics. 2006 Feb 14;24 (3) :191-7.
Product Specifications
Product Name Alternative
BDNF/NT-3 growth factors receptor precursor|| EC 2.7.10.1|| GP145-TrkB|| GP145-TrkB/GP95-TrkB|| NTRK2
Gene Name
NTRK2
Gene ID
4915
UniProt
Q16620
Host
Rabbit
Reactivity
Rat, Mouse, Human
Immunogen
Peptide sequence around phosphorylation site of tyrosine 705 (T-D-Y P-Y-R) derived from Human TrkB.
Target Antigen
TrkB (Phospho-Tyr705)
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 140kd, Western blotting: 1:500~1:1000
Isotype
Rabbit IgG
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