Polyclonal Antibody to Keratin 8 (Phospho-Ser74)
Keratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Nakamichi I, et al. (2002) Mol Biol Cell; 13 (10) : 3441-3451. Prochasson P, et al. (2002) Nucleic Acids Res; 30 (15) : 3312-3322. Pankov R, et al. (1994) Proc Natl Acad Sci U S A; 91 (3) : 873-877. Thorey IS, et al. (1993) Mol Cell Biol; 13 (11) : 6742-6751
Product Specifications
Product Name Alternative
CK 8|| CK8|| CYK8|| Cytokeratin endo A|| K8
Gene Name
KRT8
Gene ID
3856
UniProt
P05787
Host
Rabbit
Reactivity
Human
Immunogen
Peptide sequence around phosphorylation site of serine 74 (L-L-S (p) -P-L) derived from Human Keratin 8 (CK8) .
Target Antigen
Keratin 8 (Phospho-Ser74)
Clonality
Polyclonal
Applications
WB, IF
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 55kd, Western blotting: 1:500~1:1000, Immunofluorescence: 1:100~1:200
Isotype
Rabbit IgG
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